Definition of the disease Ataxia telangiectasia (AT) is an autosomal recessive disorder
primarily characterized by cerebellar degeneration, telangiectasia, immunodeficiency …

This article focuses on the functions of NF-κB that vitally impact lymphocytes and thus
adaptive immunity. NF-κB has long been known to be essential for many of the responses of …

Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …

DNA double-strand breaks (DSBs) initiate extensive local and global alterations in
chromatin structure, many of which depend on the ATM kinase. Histone H2A ubiquitylation …

The extent to which the three-dimensional organization of the genome contributes to
chromosomal translocations is an important question in cancer genomics. We generated a …

Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …

DNA damage occurs on exposure to genotoxic agents and during physiological DNA
transactions. DNA double-strand breaks (DSBs) are particularly dangerous lesions that …

The dimeric transcription factor nuclear factor κB (NF‐κB) functions broadly in coordinating
cellular responses during inflammation and immune reactions, and its importance in the …

The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …

Caspase 3 is required for the differentiation of a wide variety of cell types, yet it remains
unclear how this apoptotic protein could promote such a cell-fate decision. Caspase signals …