Approximately one-quarter of circulating cobalamin (vitamin B-12) binds to transcobalamin
(holoTC) and is thereby available for the cells of the body. For this reason, holoTC is also …

A compromised vitamin B12 status is common in older people despite dietary intakes that
typically far exceed current recommendations. The maintenance of an optimal status of …

Background Vitamin B12 is an essential micronutrient in humans needed for health
maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and …

Atherosclerosis and resulting cardiovascular disease are the leading causes of death in the
US. Hyperhomocysteinemia (HHcy), or the accumulation of the intermediate amino acid …

Background: Overweight and obesity (OO) are significant public health issues, and many
elements, including genetics, epigenetics, sedentary lifestyle, comorbid conditions …

Recent advances in the field of nutrigenetics have provided evidence on how genetic
variations can impact the individuals' response to dietary intakes. An objective and reliable …

Background: Imbalance of homocysteine (Hcy) metabolism links with several pathologies;
nevertheless, it is poorly characterized in pediatric populations. This study investigated the …

Aquaporins (AQPs) are transmembrane channels that facilitate water and glycerol
permeation through cell membranes. Recently, the water channel AQP1 was suggested to …

Vitamin B-12 is essential for the development and maintenance of a healthy nervous system.
Brain development occurs primarily in utero and early infancy, but the role of maternal …

Two polymorphic variants in the gene coding for transcobalamin II (TCN2), TCN2776C-> G
andTCN267A-> G, may alter serum holotranscobalamin (holoTC), which in turn may affect …