During the cell cycle, DNA suffers several lesions that need to be repaired prior to entry into
mitosis to preserve genome integrity in daughter cells. Toward this aim, cells have …

Understanding the mechanisms of embryonic cell cycles is a central goal of developmental
biology, as the regulation of the cell cycle must be closely coordinated with other events …

A fundamental goal of genetics and functional genomics is to identify and mutate every gene
in model organisms such as Drosophila melanogaster. The Berkeley Drosophila Genome …

Entry into mitosis requires the activity of the Cdc2 kinase. Cdc2 associates with the B-type
cyclins, and the Cdc2-cyclin B heterodimer is in turn regulated by phosphorylation …

Activation of the Cdc2· cyclin B kinase is a pivotal step of mitotic initiation. This step is
mediated principally by the dephosphorylation of residues threonine 14 (Thr 14) and …

Stages in development with rapid transitions between mitosis and morphogenesis may
require specific mechanisms to coordinate cell shape change. Here we describe a novel …

Embryogenesis is typically initiated by a series of rapid mitotic divisions that are under
maternal genetic control. The switch to zygotic control of embryogenesis at the midblastula …

Background: Cell cycle checkpoints maintain the fidelity of the somatic cell cycle by ensuring
that one step in the cell cycle is not initiated until a previous step has been completed. The …

In Drosophila embryos the maternal/zygotic transition (MZT) in cell cycle control normally
follows mitosis 13. Here we show that this transition requires degradation of two maternal …

Successful mitosis requires faithful DNA replication, spindle assembly, chromosome
segregation, and cell division. In the budding yeast Saccharomyces cerevisiae, the G2-to-M …