The case for modeling human infection in zebrafish

MC Gomes, S Mostowy - Trends in microbiology, 2020 - cell.com
Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions
in vivo because of their optical transparency, genetic manipulability, and translational …

Translating eco-evolutionary biology into therapy to tackle antibiotic resistance

F Sanz-García, T Gil-Gil, P Laborda, P Blanco… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus

A Hocher, SP Laursen, P Radford, J Tyson… - Nature …, 2023 - nature.com
Histone proteins bind DNA and organize the genomes of eukaryotes and most archaea,
whereas bacteria rely on different nucleoid-associated proteins. Homology searches have …

Biotechnological Potential of Bdellovibrio and Like Organisms and Their Secreted Enzymes

E Bratanis, T Andersson, R Lood… - Frontiers in …, 2020 - frontiersin.org
Bdellovibrio and like organisms (BALOs) are obligate predatory bacteria that selectively prey
on a broad range of Gram-negative bacteria, including multidrug-resistant human …

Bdellovibrio predation cycle characterized at nanometre-scale resolution with cryo-electron tomography

M Kaplan, YW Chang, CM Oikonomou, WJ Nicolas… - Nature …, 2023 - nature.com
Bdellovibrio bacteriovorus is a microbial predator that offers promise as a living antibiotic for
its ability to kill Gram-negative bacteria, including human pathogens. Even after six decades …

Engineered Bdellovibrio bacteriovorus: A countermeasure for biofilm-induced periodontitis

Y Tang, QX Huang, DW Zheng, Y Chen, L Ma… - Materials Today, 2022 - Elsevier
Periodontitis is caused by subgingival plaque biofilm mainly composed of Gram-negative
bacteria, affecting human populations at a high prevalence. Antibiotics therapy is the …

[HTML][HTML] Predatory bacterial hydrogels for topical treatment of infected wounds

Y Liu, B Zhuang, B Yuan, H Zhang, J Li, W Wang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Wound infection is becoming a considerable healthcare crisis due to the abuse of antibiotics
and the substantial production of multidrug-resistant bacteria. Seawater immersion wounds …

[HTML][HTML] The antibiotic crisis: How bacterial predators can help

J Pérez, FJ Contreras-Moreno, FJ Marcos-Torres… - Computational and …, 2020 - Elsevier
Discovery of antimicrobials in the past century represented one of the most important
advances in public health. Unfortunately, the massive use of these compounds in medicine …

Bdellovibrio bacteriovorus: a potential 'living antibiotic' to control bacterial pathogens

FM Cavallo, L Jordana, AW Friedrich… - Critical Reviews in …, 2021 - Taylor & Francis
Bdellovibrio bacteriovorus is a small Deltaproteobacterium which, since its discovery, has
distinguished itself for the unique ability to prey on other Gram-negative bacteria. The …

Predatory bacteria as living antibiotics–where are we now?

RJ Atterbury, J Tyson - Microbiology, 2021 - microbiologyresearch.org
Antimicrobial resistance (AMR) is a global health and economic crisis. With too few
antibiotics in development to meet current and anticipated needs, there is a critical need for …