Challenges and strategies for ocular posterior diseases therapy via non-invasive advanced drug delivery

Q Qi, Y Wei, X Zhang, J Guan, S Mao - Journal of Controlled Release, 2023 - Elsevier
Posterior segment diseases, such as age-related macular degeneration (AMD) and diabetic
retinopathy (DR) are vital factor that seriously threatens human vision health and quality of …

Amorphous solid dispersions of glycyrrhetinic acid: using soluplus, PVP, and PVPVA as the polymer matrix to enhance solubility, bioavailability, and stability

M Zhao, X Shi, J Chang, R Wang, J Zhou, P Liu - AAPS PharmSciTech, 2024 - Springer
Glycyrrhetinic acid (GA) possesses various pharmacological effects, including anti-
inflammatory, anti-tumor, and anti-viral properties. However, its clinical application is limited …

RNA-Seq-guided triple-combination nano-system of gold nanocluster, quercetin, and docetaxel for ultimate synergistic photothermal-chemotherapy against MDR …

Y Shin, M Kim, ES Lee, C Lim, KT Oh - Nano Today, 2023 - Elsevier
For oncological purposes, hyperthermia has increasingly emerged as a good therapeutic
option for patients without fitness to undergo surgery, or for those with surgically …

Preparation and characterization of lutein co-amorphous formulation with enhanced solubility and dissolution

X Song, Y Luo, W Zhao, S Liu, Y Wang, H Zhang - Foods, 2024 - mdpi.com
Lutein is an oxygenated fat-soluble carotenoid and a functional compound with proven
health benefits for the human body. Nevertheless, the poor water solubility and low oral …

Lutein–stachyose (LS) amphiphilic oligosaccharide derivatives improve the oral bioavailability of lutein

Y Li, B Liu, X Zhang, Y Liu, S Wang, S Li, X Zhao - Food Chemistry, 2023 - Elsevier
A new amphiphilic oligosaccharide derivative, based on lutein modification onto the OH
position of stachyose with facile and mild esterification, was prepared and used to improve …

Preparation and Evaluation of Siderol Amorphous Solid Dispersions: Selection of Suitable Matrix/Carrier

M Koromili, A Kapourani, A Koletti, G Papandreou… - AAPS …, 2022 - Springer
The present study investigates the preparation of amorphous solid dispersions (ASD) for the
ent-kaurane diterpenoid siderol (SDR). Initially, evaluation of the pure drug (isolated from …

[HTML][HTML] Effects of pH and palmitic acid on the organization and stability of lutein in the phosphatidylcholine membranes–Spectroscopic studies

E Reszczyńska, A Sujak, WI Gruszecki… - Journal of Molecular …, 2023 - Elsevier
This paper presents the effect of pH and the presence of palmitic acid (PA) on the
organisation and stability of lutein (LUT) in the egg yolk phosphatidylcholine (EYPC) …

Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements

H Zhang, L Dong, T Guo, G Zhang, X Ye, X He… - AAPS …, 2024 - Springer
Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-
inflammatory properties, crucial in mitigating ocular disease. However, enhancements to Lut …

Neurodevelopmental changes in Drosophila melanogaster are restored by treatment with lutein-loaded nanoparticles: Positive modulation of neurochemical and …

DE Janner, MR Poetini, EAS Musachio… - … and Physiology Part C …, 2024 - Elsevier
Neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention
deficit hyperactivity disorder (ADHD), are characterized by persistent changes in …

The presence of free palmitic acid modulates the effects of lutein on structural and dynamic properties of lipid membranes

E Reszczyńska, A Wiśniewska-Becker, M Duda… - Archives of Biochemistry …, 2024 - Elsevier
Free fatty acids, like palmitic acid (PA), and xanthophyll pigments, like lutein (LUT) are the
natural membrane compounds in plants. To study the effect of PA on LUT and their …