Mechanisms of DNA damage, repair, and mutagenesis
N Chatterjee, GC Walker - Environmental and molecular …, 2017 - Wiley Online Library
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
Repair of DNA double-strand breaks by the nonhomologous end joining pathway
BM Stinson, JJ Loparo - Annual review of biochemistry, 2021 - annualreviews.org
DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …
Structural basis of long-range to short-range synaptic transition in NHEJ
DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the
incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …
incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …
[HTML][HTML] DNA double strand break repair via non-homologous end-joining
AJ Davis, DJ Chen - Translational cancer research, 2013 - ncbi.nlm.nih.gov
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage.
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …
Accurate SAXS profile computation and its assessment by contrast variation experiments
A major challenge in structural biology is to characterize structures of proteins and their
assemblies in solution. At low resolution, such a characterization may be achieved by small …
assemblies in solution. At low resolution, such a characterization may be achieved by small …
Repair of double-strand breaks by end joining
KK Chiruvella, Z Liang… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway
DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
N Jette, SP Lees-Miller - Progress in biophysics and molecular biology, 2015 - Elsevier
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …
ModBase, a database of annotated comparative protein structure models and associated resources
U Pieper, BM Webb, GQ Dong… - Nucleic acids …, 2014 - academic.oup.com
Abstract ModBase (http://salilab. org/modbase) is a database of annotated comparative
protein structure models. The models are calculated by ModPipe, an automated modeling …
protein structure models. The models are calculated by ModPipe, an automated modeling …
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
AK Chaplin, SW Hardwick, AK Stavridi, CJ Buehl… - Molecular cell, 2021 - cell.com
Non-homologous end joining (NHEJ) is one of two critical mechanisms utilized in humans to
repair DNA double-strand breaks (DSBs). Unrepaired or incorrect repair of DSBs can lead to …
repair DNA double-strand breaks (DSBs). Unrepaired or incorrect repair of DSBs can lead to …