Advances in TRP channel drug discovery: from target validation to clinical studies

AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

TRPV4: molecular conductor of a diverse orchestra

JPM White, M Cibelli, L Urban, B Nilius… - Physiological …, 2016 - journals.physiology.org
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Molecular physiology of TRPV channels: controversies and future challenges

T Rosenbaum, LD Islas - Annual Review of Physiology, 2023 - annualreviews.org
The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Transient receptor potential channels in the vasculature

S Earley, JE Brayden - Physiological reviews, 2015 - journals.physiology.org
The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Clinical features and prognostic factors in Covid-19: a prospective cohort study

S de Bruin, LD Bos, MA van Roon, AM Tuip-de Boer… - …, 2021 - thelancet.com
Background Mortality rates are high among hospitalized patients with COVID-19, especially
in those intubated on the ICU. Insight in pathways associated with unfavourable outcome …

TRP channels as potential drug targets

MM Moran - Annual review of pharmacology and toxicology, 2018 - annualreviews.org
The transient receptor potential (TRP) superfamily of channels comprises a diverse group of
cation channels. Four TRP channel subunits coassemble to form functional homo-or …

Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration

D Križaj, S Cordeiro, O Strauß - Progress in Retinal and eye Research, 2023 - Elsevier
Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

TRPV4: a physio and pathophysiologically significant ion channel

T Rosenbaum, M Benítez-Angeles… - International journal of …, 2020 - mdpi.com
Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

TRPV4 mechanosensitive ion channel regulates lipopolysaccharide-stimulated macrophage phagocytosis

RG Scheraga, S Abraham, KA Niese… - The Journal of …, 2016 - journals.aai.org
Macrophage phagocytosis of particles and pathogens is an essential aspect of innate host
defense. Phagocytic function requires cytoskeletal rearrangements that depend on the …