Gliomas are the most frequent type of tumor in the central nervous system, which exhibit
properties that make their treatment difficult, such as cellular infiltration, heterogeneity, and …

The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to
cell death, accelerated aging features and cancer. One of the most versatile and important …

Background Nanobubbles (NBs) combined with ultrasound-targeted destruction (UTD) have
become promising potential carriers for drug or siRNA delivery. Due to their nano-size, NBs …

PURPOSE: The ataxia telangiectasia mutated (ATM) gene mediates detection and repair of
DNA damage. We investigated associations between ATM polymorphisms and severe …

In daily life, humans are exposed to the extremely low-frequency electromagnetic fields (ELF-
EMFs) generated by electric appliances, and public concern is increasing regarding the …

There are contradictory observations about the different radiosensitivities of cancer stem
cells and cancer non-stem cells. To resolve these contradictory observations, we studied …

Ataxia-telangiectasia (AT) is a rare genetic disorder caused by loss of function of the ataxia-
telangiectasia-mutated kinase and is characterized by a predisposition to cancer, pulmonary …

Evidence has shown that both high expression of the ataxia-telangiectasia mutated (ATM)
gene and glioma stem cells (GSCs) are responsible for radioresistance in glioma. Thus, we …

Radiation pneumonitis (RP) is one of the most important dose‑limiting toxicities in the
radiotherapy of thoracic tumors, which reduces the rate of local tumor control and overall …

ATM depletion is associated with the multisystemic neurodegenerative syndrome ataxia–
telangiectasia (A–T). The exact linkage between neurodegeneration and ATM deficiency …