Objective This study aimed to assess the efficacy and safety of prophylactic tranexamic acid
administration vs standard uterotonic agents alone among women undergoing cesarean …

Tranexamic acid (TXA) is a potent antifibrinolytic with documented efficacy in reducing blood
loss and allogeneic red blood cell transfusion in several clinical settings. With a growing …

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BACKGROUND Fibrinogen is a large (340 kDa) hexameric glycoprotein expressed by
hepatocytes. 1 Fibrinogen is encoded by 3 different genes (FGA, FGB, and FGG) and …

Background The optimal dose of tranexamic acid to inhibit hyperfibrinolysis in postpartum
haemorrhage is unclear. Tranexamic Acid to Reduce Blood Loss in Hemorrhagic Cesarean …

Antifibrinolytic agents such as tranexamic acid (TXA) inhibit the fibrinolytic pathway and
protect blood clots from being degraded, thereby promoting hemostasis. They have been …

Background Severe postpartum hemorrhage (PPH), defined as a blood loss≥ 1000 mL, is
associated with maternal morbidity and mortality. Objectives We aimed at characterizing …

Current research on hemostatic materials have focused on the inhibition of visible
hemorrhage, however, invisible hemorrhage is the unavoidable internal bleeding that …

Background Prophylactic use of tranexamic acid at the time of cesarean delivery has been
shown to decrease the calculated blood loss, but the effect on the need for blood …

Background In this meta-analysis, we aimed to update the clinical evidence regarding the
efficacy and safety of TXA in the prevention of PPH. Methods A literature search of PubMed …