Pharmacology of adenosine receptors: the state of the art

PA Borea, S Gessi, S Merighi… - Physiological …, 2018 - journals.physiology.org
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Cardiovascular adenosine receptors: expression, actions and interactions

JP Headrick, KJ Ashton, RB Rose'Meyer… - Pharmacology & …, 2013 - Elsevier
Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

[HTML][HTML] Adenosine and its receptors in the heart: regulation, retaliation and adaptation

JP Headrick, JN Peart, ME Reichelt… - Biochimica et Biophysica …, 2011 - Elsevier
The purine nucleoside adenosine is an important regulator within the cardiovascular system,
and throughout the body. Released in response to perturbations in energy state, among …

Adenosine-induced atrial fibrillation: localized reentrant drivers in lateral right atria due to heterogeneous expression of adenosine A1 receptors and GIRK4 subunits …

N Li, TA Csepe, BJ Hansen, LV Sul… - Circulation, 2016 - Am Heart Assoc
Background: Adenosine provokes atrial fibrillation (AF) with a higher activation frequency in
right atria (RA) versus left atria (LA) in patients, but the underlying molecular and functional …

Biochemical and Pharmacological Role of A1 Adenosine Receptors and Their Modulation as Novel Therapeutic Strategy

K Varani, F Vincenzi, S Merighi, S Gessi… - Protein Reviews: Volume …, 2017 - Springer
Adenosine, the purine nucleoside, mediates its effects through activation of four G-protein
coupled adenosine receptors (ARs) named as A 1, A 2A, A 2B and A 3. In particular, A 1 ARs …

Optimal β-blocker for prevention of atrial fibrillation after on-pump coronary artery bypass graft surgery: carvedilol versus metoprolol

M Haghjoo, M Saravi, MJ Hashemi, S Hosseini… - Heart Rhythm, 2007 - Elsevier
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia after coronary artery
bypass graft (CABG) surgery. It has been shown that prophylactic oral β-blocker …

Peri-operative oral caffeine does not prevent postoperative atrial fibrillation after heart valve surgery with cardiopulmonary bypass: a randomised controlled clinical …

D Lagier, L Nee, R Guieu, F Kerbaul… - European Journal of …, 2018 - journals.lww.com
BACKGROUND Raised plasma levels of endogenous adenosine after cardiac surgery using
cardiopulmonary bypass (CPB) have been related to the incidence of postoperative atrial …

PET imaging of adenosine receptors in diseases

J Li, X Hong, G Li, PS Conti, X Zhang… - Current Topics in …, 2019 - ingentaconnect.com
Adenosine receptors (ARs) are a class of purinergic G-protein-coupled receptors (GPCRs).
Extracellular adenosine is a pivotal regulation molecule that adjusts physiological function …

Comparison of atrial fibrillation predictors in patients with acute coronary syndrome using ticagrelor or clopidogrel

E Algül, H Sunman, M Dural, I Guliyev… - Turkish journal of …, 2019 - journals.tubitak.gov.tr
Background/aim: Ticagrelor is a drug widely used in patients with acute coronary syndromes
(ACS) that specifically increases the plasma level of adenosine, which is likely to cause …

Postoperative rhythm disorders after adult cardiac surgery

M Haghjoo - Postoperative Critical Care for Adult Cardiac Surgical …, 2018 - Springer
New-onset arrhythmias are a common complication of cardiac surgery. Atrial fibrillation is
the most common arrhythmia encountered postoperatively, although ventricular arrhythmias …