Antigenicity and receptor affinity of SARS-CoV-2 BA. 2.86 spike

Q Wang, Y Guo, L Liu, LT Schwanz, Z Li, MS Nair, J Ho… - Nature, 2023 - nature.com
A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant, BA.
2.86, has emerged and spread to numerous countries worldwide, raising alarm because its …

Fast evolution of SARS-CoV-2 BA. 2.86 to JN. 1 under heavy immune pressure

S Yang, Y Yu, Y Xu, F Jian, W Song… - The Lancet Infectious …, 2024 - thelancet.com
The SARS-CoV-2 saltation variant BA. 2.86, which was quickly designated as a variant
under monitoring after its emergence, has garnered global attention. Although BA. 2.86 did …

[HTML][HTML] Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine

Q Wang, Y Guo, AR Tam, R Valdez, A Gordon, L Liu… - Cell Reports …, 2023 - cell.com
To combat the evolving SARS-CoV-2 Omicron variants, bivalent COVID-19 mRNA vaccines,
encoding both ancestral and Omicron BA. 5 spikes, have replaced monovalent vaccines in …

Passive antibody therapy in emerging infectious diseases

X Yang - Frontiers of Medicine, 2023 - Springer
The epidemic of corona virus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome Coronavirus 2 and its variants of concern (VOCs) has been ongoing for over 3 …

Sotrovimab: A Review of Its Efficacy against SARS-CoV-2 Variants

D Focosi, A Casadevall, M Franchini, F Maggi - Viruses, 2024 - mdpi.com
Among the anti-Spike monoclonal antibodies (mAbs), the S-309 derivative sotrovimab was
the most successful in having the longest temporal window of clinical use, showing a high …

Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN. 1 sublineages

Q Wang, IA Mellis, J Ho, A Bowen… - Emerging Microbes & …, 2024 - Taylor & Francis
The recently dominant SARS-CoV-2 Omicron JN. 1 has evolved into multiple sublineages,
with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth …

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

L Liu, RG Casner, Y Guo, Q Wang, S Iketani, JFW Chan… - bioRxiv, 2023 - biorxiv.org
SUMMARY SARS-CoV-2 continues to evolve and evade most existing neutralizing
antibodies, including all clinically authorized antibodies. We have isolated and …

SARS-CoV-2 Omicron subvariants progressively adapt to human cells with altered host cell entry

Y Sakurai, S Okada, T Ozeki, R Yoshikawa, T Kinoshita… - Msphere, 2024 - journals.asm.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant
exhibits high transmissibility with a strong immune escape ability and causes frequent large …

The wind of change: Gibbs energy of binding and infectivity evolution of Omicron BA. 2.86 Pirola, EG. 5.1, XBB. 1.16 Arcturus, CH. 1.1 and BN. 1 variants of SARS-CoV …

ME Popović, G Šekularac, M Popović - Microbial Risk Analysis, 2024 - Elsevier
A question is often asked about what tomorrow brings. During the last 4 years of the COVID-
19 pandemic, this question was asked with every appearance of a new SARS-CoV-2 …

Temperature-dependent Spike-ACE2 interaction of Omicron subvariants is associated with viral transmission

M Benlarbi, S Ding, É Bélanger, A Tauzin, R Poujol… - Mbio, 2024 - journals.asm.org
The continued evolution of severe acute respiratory syndrome 2 (SARS-CoV-2) requires
persistent monitoring of its subvariants. Omicron subvariants are responsible for the vast …