Evaluation of a photodynamic therapy agent using a canine prostate cancer model

D Luo, X Wang, G Ramamurthy, E Walker… - The …, 2023 - Wiley Online Library
Background Male dogs can develop spontaneous prostate cancer, which is similar
physiologically to human disease. Recently, Tweedle and coworkers have developed an …

Effect of dickkopf-1 (Dkk-1) and SP600125, a JNK inhibitor, on Wnt signaling in canine prostate cancer growth and bone metastases

W Supsavhad, BB Hassan, JK Simmons… - Veterinary …, 2021 - mdpi.com
Human Dickkopf-1 (Dkk-1) upregulates a noncanonical Wnt/JNK pathway, resulting in
osteoclast stimulation, cell proliferation, and epithelial-to-mesenchymal transition (EMT) of …

Stability evaluation and stabilization of a gastrin-releasing peptide receptor (GRPR) targeting imaging pharmaceutical

A Ghosh, K Woolum, S Kothandaraman, MF Tweedle… - Molecules, 2019 - mdpi.com
The prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor
(GRPR) are identified as important targets on prostate cancer. Receptor-targeting …

Novel Peptide NIRF Optical Surgical Navigation Agents for HNSCC

H Ding, S Kothandaraman, L Gong, CL Wright, Q Pan… - Molecules, 2019 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) survival rates have not improved in a
decade, with a 63% 5-year recurrence rate after surgery, making HNSCC a compelling …

Extracellular ATP and macropinocytosis: their interactive and mutually supportive roles in cell growth, drug resistance, and EMT in cancer

M Evers, J Song, X Chen - Macropinocytosis: Functions and Mechanisms, 2022 - Springer
Macropinocytosis is one of the major mechanisms by which cancer cells uptake extracellular
nutrients from tumor microenvironment (TME) and plays very important roles in various steps …

[PDF][PDF] The Current Status of Prostate Cancer Animal Models

Y Jiang, Q Song, D Cao, H Guo… - J. Vet. Med. Anim …, 2020 - meddocsonline.org
Prostate Cancer (PCA) is the most common malignant tumor in urinary system of men in
Europe and the United States. It ranks second in male cancer mortality, only behind to lung …