Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional
groups to explore and understand biology in living organisms. In this review, we summarize …

Neurons are among the most compartmentalized and interactive of all cell types. Like all
cells, neurons use proteins as the main sensors and effectors. The modification of the …

METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …

Recently, click chemistry has provided important advances in biomedical research fields.
Particularly, copper-free click chemistry including strain-promoted azide–alkyne …

The function of cells in their native habitat often cannot be reliably predicted from genomic
data or from physiology studies of isolates. Traditional experimental approaches to study the …

Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that
also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out …

In the past 15 years, there have been rapid developments in the ability to cotranslationally
incorporate unnatural amino acids into proteins produced in cells, both at defined sites via …

Translation is the fundamental biological process converting mRNA information into
proteins. Single-molecule imaging in live cells has illuminated the dynamics of RNA …

Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …