The role of transcription factor PPAR-γ in the pathogenesis of psoriasis, skin cells, and immune cells

VV Sobolev, E Tchepourina, IM Korsunskaya… - International Journal of …, 2022 - mdpi.com
The peroxisome proliferator-activated receptor PPAR-γ is one of three PPAR nuclear
receptors that act as ligand-activated transcription factors. In immune cells, the skin, and …

Metabolic disorders and psoriasis: exploring the role of nutritional interventions

M Cintoni, M Palombaro, FS Maramao, P Raoul… - Nutrients, 2023 - mdpi.com
(1) Background: Psoriasis is a chronic autoimmune disease with a close relationship with
metabolic diseases such as obesity, diabetes, and dyslipidemia. The aim of this review was …

Roles of PPAR activation in cancer therapeutic resistance: Implications for combination therapy and drug development

Y Zhang, B Xiao, Y Liu, S Wu, Q Xiang, Y Xiao… - European Journal of …, 2024 - Elsevier
Therapeutic resistance is a major obstacle to successful treatment or effective containment
of cancer. Peroxisome proliferator-activated receptors (PPARs) play an essential role in …

A possible modulator of vitiligo metabolic impairment: rethinking a PPARγ agonist

F Papaccio, B Bellei, M Ottaviani, A D'Arino, M Truglio… - Cells, 2022 - mdpi.com
Vitiligo is a complex disease wherein derangements in multiple pathways determine the loss
of functional melanocytes. Since its pathogenesis is not yet completely understood, vitiligo …

Site-Specifically launched microneedles for the combined treatment of psoriasis-diabetic comorbidity

X Gao, F Zhang, Y Huang, W Hu, Y Chen… - … Applied Materials & …, 2023 - ACS Publications
Psoriasis and diabetes are both common comorbidities for each other, where inflammation
and insulin resistance act in a vicious cycle, driving the progression of disease through the …

Trace elements and oxidative stress status in patients with psoriasis

A Kirmit, S Kader, M Aksoy, C Bal, C Nural… - … in Dermatology and …, 2020 - termedia.pl
Trace elements and oxidative stress status in patients with psoriasis Page 1 Advances in
Dermatology and Allergology 3, June/2020 333 This is an Open Access article distributed under …

Pioglitazone as a potential modulator in autoimmune diseases: a review on its effects in systemic lupus erythematosus, psoriasis, inflammatory bowel disease, and …

ME Nasrabadi, A Al-Harrasi… - Expert Review of …, 2024 - Taylor & Francis
Introduction Current medications for autoimmune disorders often induce broad-ranging side
effects, prompting a growing interest in therapies with more specific immune system …

Is metformin a possible beneficial treatment for psoriasis? A scoping review

AMA Stanescu, AA Simionescu, M Florea… - Journal of Personalized …, 2021 - mdpi.com
Psoriasis is a chronic inflammatory condition with genetic, immunological, and metabolic
etiology. The link between psoriasis and diabetes mellitus has been shown in genetic …

Plasma proteomics associated with autoimmune coagulation factor deficiencies reveals the link between inflammation and autoantibody development

T Osaki, M Souri, A Ichinose - International Journal of Hematology, 2022 - Springer
Autoimmune coagulation factor deficiency (AiCFD) is characterized by sudden excessive
bleeding due to autoantibodies against coagulation factors. This occurs primarily in elderly …

Effects of antidiabetic drugs on psoriasis: a meta‐analysis

CC Chi, CY Lee, CY Liu, SH Wang… - European Journal of …, 2021 - Wiley Online Library
Background Psoriasis, a chronic inflammatory skin disease, poses an elevated risk of
developing diabetes mellitus. Purpose To investigate the effects of antidiabetic medications …