Influence of the nutritional status and oxidative stress in the desaturation and elongation of n-3 and n-6 polyunsaturated fatty acids: Impact on non-alcoholic fatty liver …

LA Videla, MC Hernandez-Rodas, AH Metherel… - … and Essential Fatty …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFA) play essential roles in cell membrane structure and
physiological processes including signal transduction, cellular metabolism and tissue …

Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion

AH Metherel, RP Bazinet - Progress in Lipid Research, 2019 - Elsevier
N-3 polyunsaturated fatty acids (PUFA) and the numerous families of lipid mediators derived
from them collectively regulate numerous biological processes. The mechanisms by which n …

Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency

R Valenzuela, AH Metherel, G Cisbani, ME Smith… - Biofactors, 2024 - Wiley Online Library
The synthesis rates of n‐3 and n‐6 polyunsaturated fatty acids (PUFAs) in rodents and
humans are not agreed upon and depend on substrate availability independently of the …

Blood and tissue docosahexaenoic acid (DHA, 22: 6n-3) turnover rates from Ahiflower® oil are not different than from DHA ethyl ester oil in a diet switch mouse model

AH Metherel, BJ Klievik, G Cisbani, ME Smith… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Ahiflower® oil is high in α-linolenic and stearidonic acids, however, tissue/blood
docosahexaenoic acid (DHA, 22: 6n-3) turnover from dietary Ahiflower oil has not been …

[HTML][HTML] Metabolic fate of DHA from regio-and stereospecific positions of triacylglycerols in a long-term feeding trial in rats

Y Zhang, M Kalpio, L Tao, GG Haraldsson… - Food Research …, 2023 - Elsevier
This study investigated the impact of regio-and stereospecific position of docosahexaenoic
acid (DHA) in dietary triacylglycerols (TAGs) on the fatty acid composition of tissues and …

[HTML][HTML] Perspective: moving toward desirable linoleic acid content in infant formula

SE Carlson, L Schipper, JT Brenna, C Agostoni… - Advances in …, 2021 - Elsevier
Infant formula should provide the appropriate nutrients and adequate energy to facilitate
healthy infant growth and development. If conclusive data on quantitative nutrient …

Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation

AH Metherel, R Valenzuela, BJ Klievik, G Cisbani… - Journal of Lipid …, 2024 - ASBMB
DHA is abundant in the brain where it regulates cell survival, neurogenesis, and
neuroinflammation. DHA can be obtained from the diet or synthesized from alpha-linolenic …

Dietary LA and sex effects on oxylipin profiles in rat kidney, liver, and serum differ from their effects on PUFAs

S Leng, T Winter, HM Aukema - Journal of lipid research, 2017 - ASBMB
A vast literature on fatty acids in mammals exists, but comparable compositional data on
oxylipins is lacking. Weanling Sprague-Dawley rats were therefore provided control diets or …

Dietary ALA, EPA and DHA have distinct effects on oxylipin profiles in female and male rat kidney, liver and serum

S Leng, T Winter, HM Aukema - The Journal of nutritional biochemistry, 2018 - Elsevier
There is much data on the effects of dietary n-3 fatty acids on tissue fatty acid compositions,
but comparable comprehensive data on their oxygenated metabolites (oxylipins) is limited …

Tissue-specific content of polyunsaturated fatty acids in (n-3) deficiency state of rats

A Kulkarni, A Zhao, B Yang, Y Zhang, KM Linderborg - Foods, 2022 - mdpi.com
The dietary intake of fatty acids (FAs) affects the composition and distribution of FAs in the
body. Here, a first-generation (n-3)-deficiency study was conducted by keeping young (age …