Mechanisms of photoreceptor death in retinitis pigmentosa

F Newton, R Megaw - Genes, 2020 - mdpi.com
Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

D Athanasiou, M Aguila, J Bellingham, W Li… - Progress in retinal and …, 2018 - Elsevier
Inherited mutations in the rod visual pigment, rhodopsin, cause the degenerative blinding
condition, retinitis pigmentosa (RP). Over 150 different mutations in rhodopsin have been …

The mechanism of cone cell death in Retinitis Pigmentosa

PA Campochiaro, TA Mir - Progress in retinal and eye research, 2018 - Elsevier
Retinitis Pigmentosa (RP) is a group of diseases in which one of a large number of
mutations causes death of rod photoreceptors. After rods die, cone photoreceptors slowly …

Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases

N Cuenca, L Fernández-Sánchez, L Campello… - Progress in retinal and …, 2014 - Elsevier
Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

Tauroursodeoxycholate—bile acid with chaperoning activity: molecular and cellular effects and therapeutic perspectives

M Kusaczuk - Cells, 2019 - mdpi.com
Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

[HTML][HTML] Retinitis pigmentosa: novel therapeutic targets and drug development

KY Wu, M Kulbay, D Toameh, AQ Xu, A Kalevar… - Pharmaceutics, 2023 - mdpi.com
Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by
progressive degeneration of retinal photoreceptors leading to progressive visual decline. It …

Proliferative vitreoretinopathy: a new concept of disease pathogenesis and practical consequences

JC Pastor, J Rojas, S Pastor-Idoate, S Di Lauro… - Progress in retinal and …, 2016 - Elsevier
During the last four decades, proliferative vitreoretinopathy (PVR) has defied the efforts of
many researchers to prevent its occurrence or development. Thus, PVR is still the major …

[HTML][HTML] Neuroprotective strategies for retinal disease

MT Pardue, RS Allen - Progress in retinal and eye research, 2018 - Elsevier
Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and
glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of …

Retinitis pigmentosa: progress in molecular pathology and biotherapeutical strategies

W Liu, S Liu, P Li, K Yao - International Journal of Molecular Sciences, 2022 - mdpi.com
Retinitis pigmentosa (RP) is genetically heterogeneous retinopathy caused by
photoreceptor cell death and retinal pigment epithelial atrophy that eventually results in …

[HTML][HTML] Bile acids and neurological disease

MJ Hurley, R Bates, J Macnaughtan… - Pharmacology & …, 2022 - Elsevier
This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …