Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - Elsevier
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

[HTML][HTML] Cellular circuits in the brain and their modulation in acute and chronic pain

R Kuner, T Kuner - Physiological reviews, 2020 - journals.physiology.org
Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Hormonal influences in migraine—interactions of oestrogen, oxytocin and CGRP

DN Krause, K Warfvinge, KA Haanes… - Nature Reviews …, 2021 - nature.com
Migraine is ranked as the second highest cause of disability worldwide and the first among
women aged 15–49 years. Overall, the incidence of migraine is threefold higher among …

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

J Wahis, A Baudon, F Althammer, D Kerspern… - Nature …, 2021 - nature.com
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural
circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby …

Amygdala, neuropeptides, and chronic pain-related affective behaviors

V Neugebauer, M Mazzitelli, B Cragg, G Ji… - …, 2020 - Elsevier
Neuropeptides play important modulatory roles throughout the nervous system, functioning
as direct effectors or as interacting partners with other neuropeptide and neurotransmitter …

Role of estrogens in menstrual migraine

RE Nappi, L Tiranini, S Sacco, E De Matteis, R De Icco… - Cells, 2022 - mdpi.com
Migraine is a major neurological disorder affecting one in nine adults worldwide with a
significant impact on health care and socioeconomic systems. Migraine is more prevalent in …

The oxytocin–vasopressin pathway in the context of love and fear

CS Carter - Frontiers in endocrinology, 2017 - frontiersin.org
Vasopressin (VP) and oxytocin (OT) are distinct molecules; these peptides and their
receptors [OT receptor (OTR) and V1a receptor (V1aR)] also are evolved components of an …

Prolactin and oxytocin: potential targets for migraine treatment

AK Szewczyk, S Ulutas, T Aktürk, L Al-Hassany… - The Journal of …, 2023 - Springer
Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully
understood. Besides the role of inflammatory mediators that interact with the …

Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures

M Filippa, MG Monaci, C Spagnuolo, P Serravalle… - Scientific Reports, 2021 - nature.com
Preterm infants undergo early separation from parents and are exposed to frequent painful
clinical procedures, with resultant short-and long-term effects on their neurodevelopment …

Oxytocin and oxygen: the evolution of a solution to the 'stress of life'

CS Carter, MA Kingsbury - Philosophical Transactions of …, 2022 - royalsocietypublishing.org
Oxytocin (OT) and the OT receptor occupy essential roles in our current understanding of
mammalian evolution, survival, sociality and reproduction. This narrative review examines …