Modulation of intracellular copper levels as the mechanism of action of anticancer copper complexes: Clinical relevance
Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
Imaging tumour hypoxia with positron emission tomography
Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its
association with an aggressive tumour phenotype and therapeutic resistance. Given its …
association with an aggressive tumour phenotype and therapeutic resistance. Given its …
Targeting hypoxia to improve non–small cell lung cancer outcome
A Salem, MC Asselin, B Reymen… - JNCI: Journal of the …, 2018 - academic.oup.com
Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …
Hypoxia and the phenomenon of immune exclusion
V Pietrobon, FM Marincola - Journal of Translational Medicine, 2021 - Springer
Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …
it is nowadays considered a promising strategy against many types of cancer. However, the …
Molecular mechanisms of hypoxia in cancer
A Challapalli, L Carroll, EO Aboagye - Clinical and translational imaging, 2017 - Springer
Purpose Hypoxia is a condition of insufficient oxygen to support metabolism which occurs
when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is …
when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is …
PET/CT imaging in different types of lung cancer: an overview
V Ambrosini, S Nicolini, P Caroli, C Nanni… - European journal of …, 2012 - Elsevier
Lung cancer (LC) still represents one of the most common tumours in both women and men.
PET/CT is a whole-body non-invasive imaging procedure that has been increasingly used …
PET/CT is a whole-body non-invasive imaging procedure that has been increasingly used …
Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study
M Ikawa, H Okazawa, T Tsujikawa, A Matsunaga… - Neurology, 2015 - AAN Enterprises
Objective: To investigate cerebral oxidative stress based on an over-reductive state caused
by mitochondrial dysfunction and its relationship to disease severity in patients with …
by mitochondrial dysfunction and its relationship to disease severity in patients with …
Imaging of tumor hypoxia with radionuclide-labeled tracers for PET
Y Huang, J Fan, Y Li, S Fu, Y Chen, J Wu - Frontiers in Oncology, 2021 - frontiersin.org
The hypoxic state in a solid tumor refers to the internal hypoxic environment that appears as
the tumor volume increases (the maximum radius exceeds 180-200 microns). This state can …
the tumor volume increases (the maximum radius exceeds 180-200 microns). This state can …
Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms
T Liu, M Karlsen, AM Karlberg, KR Redalen - EJNMMI research, 2020 - Springer
Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid
tumor environment, associated with malignant progression, radiotherapy resistance, and …
tumor environment, associated with malignant progression, radiotherapy resistance, and …
Advances in PET and MRI imaging of tumor hypoxia
Tumor hypoxia is a complex and evolving phenomenon both in time and space. Molecular
imaging allows to approach these variations, but the tracers used have their own limitations …
imaging allows to approach these variations, but the tracers used have their own limitations …