Hyperinsulinemia, an overlooked clue, and potential way forward in metabolic dysfunction-associated steatotic liver disease

SA Harrison, J Dubourg, M Knott, J Colca - Hepatology, 2023 - journals.lww.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with
other features of the metabolic syndrome such as type 2 diabetes. The progression of the …

Envisioning how to advance the MASH field

AM Allen, ZM Younossi, AM Diehl… - Nature Reviews …, 2024 - nature.com
Since 1980, the cumulative effort of scientists and health-care stakeholders has advanced
the prerequisites to address metabolic dysfunction-associated steatotic liver disease …

[HTML][HTML] Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH

J Conway, M Pouryahya, Y Gindin, DZ Pan… - Cell Reports …, 2023 - cell.com
Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease globally and
a leading cause for liver transplantation in the US. Its pathogenesis remains imprecisely …

Clinical trial: effects of pegozafermin on the liver and on metabolic comorbidities in subjects with biopsy‐confirmed nonalcoholic steatohepatitis

N Alkhouri, D Lazas, R Loomba, JP Frias… - Alimentary …, 2023 - Wiley Online Library
Background An approved therapy for nonalcoholic steatohepatitis (NASH) and fibrosis
remains a major unmet medical need. Aim To investigate the histological and metabolic …

[HTML][HTML] NAFLD (MASLD)/NASH (MASH): Does It Bother to Label at All? A Comprehensive Narrative Review

CM Sergi - International Journal of Molecular Sciences, 2024 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), or metabolic dysfunction-associated steatotic liver
disease (MASLD), is a liver condition that is linked to overweight, obesity, diabetes mellitus …

Liver Biopsy Evaluation in MASH Drug Development: Think Thrice, Act Wise

SA Harrison, J Dubourg - Journal of Hepatology, 2024 - Elsevier
With an estimated global prevalence of 30%, the most common chronic liver disease namely
metabolic dysfunction-associated steatotic liver disease (MASLD) is closely entangled with …