Central adrenal insufficiency (CAI) is a life-threatening condition caused by either pituitary
disease (secondary adrenal insufficiency) or impaired hypothalamic function with …

The first description of patients with combined pituitary hormone deficiencies (CPHD)
caused by PROP1 mutations was made 20 years ago. Here we updated the clinical and …

Pituitary hormone deficiency occurs in∼ 1: 4,000 live births. Approximately 3% of the cases
are due to mutations in the alpha isoform of POU1F1, a pituitary-specific transcriptional …

Background and Objectives: Combined pituitary hormone deficiency (CPHD) is a rare
heterogeneous disease. It is characterized by the deficiency of growth hormone (GH) and …

Mouse models of growth hormone deficiency (GHD) have provided important tools for
uncovering the various actions of GH. Nearly 100 years of research using these mouse lines …

There are only a few published studies related to the population‐based etiology of
hypopituitarism. New risks for developing hypopituitarism have been recognized in the last …

Background POU1F1 encodes both PIT-1α, which plays pivotal roles in pituitary
development and GH, PRL and TSHB expression, and the alternatively spliced isoform PIT …

Context POU1F1 mutations are prevalent in Indian CPHD cohorts. Genotype–phenotype
correlation is not well-studied. Aim To describe phenotypic and genotypic spectrum of …

Context Regional variation in prevalence of genetic mutations in growth hormone deficiency
(GHD) is known. Aim Study phenotype and prevalence of mutations in GH1, GHRHR …

Nivalenol (NIV), a type B trichothecenes commonly found in cereal crops, can cause growth
impairment in animals. However, limited information about its mechanisms is available …