Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia
Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available
medications. Thus, understanding the neural basis of these deficits is crucial for the …
medications. Thus, understanding the neural basis of these deficits is crucial for the …
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
DA Lewis, AA Curley, JR Glausier, DW Volk - Trends in neurosciences, 2012 - cell.com
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia
LA Glantz, DA Lewis - Archives of general psychiatry, 2000 - jamanetwork.com
Background The pathophysiological characteristics of schizophrenia appear to involve
altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that …
altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that …
Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
T Hashimoto, DW Volk, SM Eggan… - Journal of …, 2003 - Soc Neuroscience
Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects
with schizophrenia, and several lines of evidence suggest that these alterations may be …
with schizophrenia, and several lines of evidence suggest that these alterations may be …
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
S Akbarian, JJ Kim, SG Potkin… - Archives of general …, 1995 - jamanetwork.com
Background: Up-regulation of γ-aminobutyric acid A (GABA A) receptors and decreased
GABA uptake in the cerebral cortex of schizophrenics suggest altered GABAergic …
GABA uptake in the cerebral cortex of schizophrenics suggest altered GABAergic …
Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical γ-aminobutyric acid neurons in subjects with schizophrenia
DW Volk, MC Austin, JN Pierri… - Archives of general …, 2000 - jamanetwork.com
Background Markers of γ-aminobutyric acid (GABA) neurotransmission seem to be altered in
the prefrontal cortex (PFC) of subjects with schizophrenia. We sought to determine whether …
the prefrontal cortex (PFC) of subjects with schizophrenia. We sought to determine whether …
COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.
WE Kaufmann, PF Worley, J Pegg… - Proceedings of the …, 1996 - National Acad Sciences
Postnatal development and adult function of the central nervous system are dependent on
the capacity of neurons to effect long-term changes of specific properties in response to …
the capacity of neurons to effect long-term changes of specific properties in response to …
Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: clinical, protein, and cell type-specific features
AA Curley, D Arion, DW Volk… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: Cognitive deficits in schizophrenia are associated with altered activity of the
dorsolateral prefrontal cortex, which has been attributed to lower expression of the 67 kDa …
dorsolateral prefrontal cortex, which has been attributed to lower expression of the 67 kDa …
GABAergic neurons and their role in cortical plasticity in primates
EG Jones - Cerebral cortex, 1993 - academic.oup.com
GABA neurons and GABA receptors are conspicuous elements of cerebral cortical
organization. They serve to shape the stimulus-response properties of neurons in the …
organization. They serve to shape the stimulus-response properties of neurons in the …
Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters
HS Huang, A Matevossian, C Whittle… - Journal of …, 2007 - Soc Neuroscience
Alterations in GABAergic mRNA expression play a key role for prefrontal dysfunction in
schizophrenia and other neurodevelopmental disease. Here, we show that histone H3 …
schizophrenia and other neurodevelopmental disease. Here, we show that histone H3 …