Towards a genomics-informed, real-time, global pathogen surveillance system

JL Gardy, NJ Loman - Nature Reviews Genetics, 2018 - nature.com
Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

Tracking virus outbreaks in the twenty-first century

ND Grubaugh, JT Ladner, P Lemey, OG Pybus… - Nature …, 2019 - nature.com
Emerging viruses have the potential to impose substantial mortality, morbidity and economic
burdens on human populations. Tracking the spread of infectious diseases to assist in their …

Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks

AK Keita, FR Koundouno, M Faye, A Düx, J Hinzmann… - Nature, 2021 - nature.com
Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the
country faced a new outbreak—between 14 February and 19 June 2021—near the …

Virus genomes reveal factors that spread and sustained the Ebola epidemic

G Dudas, LM Carvalho, T Bedford, AJ Tatem, G Baele… - Nature, 2017 - nature.com
Abstract The 2013–2016 West African epidemic caused by the Ebola virus was of
unprecedented magnitude, duration and impact. Here we reconstruct the dispersal …

The evolution of Ebola virus: Insights from the 2013–2016 epidemic

EC Holmes, G Dudas, A Rambaut, KG Andersen - Nature, 2016 - nature.com
The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented
magnitude and changed our perspective on this lethal but sporadically emerging virus. This …

Scalable relaxed clock phylogenetic dating

EM Volz, SDW Frost - Virus evolution, 2017 - academic.oup.com
Molecular clock models relate observed genetic diversity to calendar time, enabling
estimation of times of common ancestry. Many large datasets of fast-evolving viruses are not …

Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors

J Liu, JC Trefry, AM Babka, CW Schellhase… - Science translational …, 2022 - science.org
Effective therapeutics have been developed against acute Ebola virus disease (EVD) in both
humans and experimentally infected nonhuman primates. However, the risk of viral …

Safety and immunogenicity of a 2-dose heterologous vaccine regimen with Ad26. ZEBOV and MVA-BN-Filo Ebola vaccines: 12-month data from a phase 1 …

G Mutua, O Anzala, K Luhn, C Robinson… - The Journal of …, 2019 - academic.oup.com
Abstract Background During the 2014 West African Ebola outbreak, Ebola vaccine
development was accelerated. The phase 1 VAC52150EBL1003 study was performed to …

Ebola virus transmission initiated by relapse of systemic Ebola virus disease

P Mbala-Kingebeni, C Pratt… - … England Journal of …, 2021 - Mass Medical Soc
During the 2018–2020 Ebola virus disease (EVD) outbreak in North Kivu province in the
Democratic Republic of Congo, EVD was diagnosed in a patient who had received the …

Identification and pathological characterization of persistent asymptomatic Ebola virus infection in rhesus monkeys

X Zeng, CD Blancett, KA Koistinen… - Nature …, 2017 - nature.com
Ebola virus (EBOV) persistence in asymptomatic humans and Ebola virus disease (EVD)
sequelae have emerged as significant public health concerns since the 2013–2016 EVD …