Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

Ion channels and transporters move ions across membrane barriers and are essential for a
host of cell functions in many organs. They conduct K+, Na+ and Cl−, which are essential for …

B cell receptor (BCR) engagement induces naive B cells to differentiate and perform critical
immune-regulatory functions. Acquisition of functional specificity requires that a cell survive …

To maintain healthy mitochondrial enzyme content and function, mitochondria possess a
complex protein quality control system, which is composed of different endogenous sets of …

The transition from immunoglobulin M (IgM) to affinity-matured IgG antibodies is vital for
effective humoral immunity. This is facilitated by germinal centers (GCs) through affinity …

Chitosan oligosaccharide (COS) is an attractive immunopotentiator capable of driving
humoral immunity in vertebrates, but its cellular and molecular mechanisms still require …

The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated
Ca 2+(CRAC) channels in T cells is well established. In contrast, the contribution of …

Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) are ER Ca 2+-release channels
that control a broad set of cellular processes. Animal models lacking IP 3 Rs in different …

Allergy and autoimmune diseases are characterised by a multifactorial pathogenic
background. Several genes involved in the control of innate and adaptive immunity have …