Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Cardiorespiratory fitness (CRF) refers to the capacity of the circulatory and respiratory
systems to supply oxygen to skeletal muscle mitochondria for energy production needed …

Immunomodulatory therapy has become a promising method for the clinical treatment of
many diseases. Recently, pilot studies revealed that immunomodulatory therapy exhibited …

Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Background: Understanding the effect of lifestyle and genetic risk on the lifetime risk of
coronary heart disease (CHD) is important to improving public health initiatives. Our …

Biologic sex influences many variables that are important to brain health in general, and to
stroke or cerebral ischemia in particular, such as general health status, cerebrovascular …

The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

Extracellular superoxide dismutase (EcSOD) is the only extracellular scavenger of
superoxide anion (O 2.-) with unique binding capacity to cell surface and extracellular matrix …

Technological advances in characterizing molecular heterogeneity at the single cell level
have ushered in a deeper understanding of the biological diversity of cells present in tissues …

Ischemic stroke is a cerebrovascular disease with high morbidity, high mortality, and high
disability, representing a serious threat to human life and health. Clinically, the extensive …