Sirtuins are a class of enzymes with nicotinamide adenine dinucleotide (NAD)-dependent
protein lysine deacylase function. By deacylating various substrate proteins, including …

Malaria remains one of the most deadly infectious diseases globally. Considering the
growing spread of resistance, development of new and effective antimalarials remains an …

The unpretentious features of acridine‐1, 8‐diones viz. presence of N‐heteroatom,
electronic behavior, acridine ring skeleton and wide possibilities of diversified substitution …

Here, an efficient heterogeneous catalytic system, made of graphene oxide (GO) nano-
sheets, iron oxide nanoparticles (Fe 3 O 4 NPs), and creatine (CR), is presented. Firstly, this …

Sirtuins are NAD+-dependent deac (et) ylases with different subcellular localization. The
sirtuins' family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates …

A simple, efficient and cost-effective method for the synthesis of 9-aryl-hexahydro-acridine-1,
8-diones by a one-pot four-component cyclocondensation of dimedone, aromatic aldehydes …

In prostate and breast cancer, the androgen and estrogen receptors mediate induction of
androgen-and estrogen-responsive genes respectively, and stimulate cell proliferation in …

The reactivity of aldehydes and ketones carries great potential for multicomponent
heterocyclizations. These reactions are convergent and highly versatile in the development …

An expeditious microwave-assisted one-pot synthesis of new cytotoxic phenanthrene fused-
tetrahydrodibenzo-acridinones has been successfully accomplished. This protocol offers …

Breast cancer (BC) is the most common type of cancer in women worldwide; it is a
multifactorial genetic disease. Acetylation and deacetylation are major post-translational …