Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Cholera is an ancient disease that remains a public health problem in many impoverished
locations around the world. Seven pandemics of cholera have been recorded since the first …

The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

BACKGROUND When human populations expanded across the globe, they adapted
genetically to local environments in response to novel selection pressures. Drivers of …

Cholera, caused by Vibrio cholerae, persists in developing countries due to inadequate
access to safe water, sanitation, and hygiene. There are approximately 4 million cases and …

India, occupying the center stage of Paleolithic and Neolithic migrations, has been
underrepresented in genome-wide studies of variation. Systematic analysis of genome-wide …

Cyclic dinucleotides (CDNs) have been previously recognized as important secondary
signaling molecules in bacteria and, more recently, in mammalian cells. In the former case …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

Human genetic diversity is the result of population genetic forces. This genetic variation
influences disease risk and contributes to health disparities. Autoimmune diseases (ADs) …

Highlights•The advent of the genome-wide association study (GWAS) approach provides a
promising framework for dissecting the genetic basis of bacterial or archaeal …