Current advancements in spinal cord Injury Research—glial scar formation and neural regeneration

T Clifford, Z Finkel, B Rodriguez, A Joseph, L Cai - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

[HTML][HTML] Engineering strategies and optimized delivery of exosomes for theranostic application in nerve tissue

Q Li, X Fu, Y Kou, N Han - Theranostics, 2023 - ncbi.nlm.nih.gov
Severe injuries or diseases affecting the peripheral and central nervous systems can result
in impaired organ function and permanent paralysis. Conventional interventions, such as …

Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury

H Suzuki, Y Imajo, M Funaba, H Ikeda… - International Journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological
deficit and social and financial burdens. It is currently being managed symptomatically, with …

Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential

BF Ribeiro, BC da Cruz, BM de Sousa, PD Correia… - Brain, 2023 - academic.oup.com
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …

Cell development enhanced bionic silk hydrogel on remodeling immune pathogenesis of spinal cord injury via m2 polarization of microglial

J Ling, T Huang, R Wu, C Ma, G Lin… - Advanced Functional …, 2023 - Wiley Online Library
Due to the complex spatial‐temporal pathophysiology of spinal cord injury (SCI), effective
modulation of SCI‐specific inflammatory pathogenesis to achieve desirable therapeutic …

How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?

N Hejrati, R Wong, M Khazaei… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …

Multilevel neurium-mimetic individualized graft via additive manufacturing for efficient tissue repair

L Kong, X Gao, X Yao, H Xie, Q Kang, W Sun… - Nature …, 2024 - nature.com
Complicated peripheral nerve injuries or defects, especially at branching sites, remain a
prominent clinical challenge after the application of different treatment strategies. Current …

Advancing spinal cord injury treatment through stem cell therapy: A comprehensive review of cell types, challenges, and emerging technologies in regenerative …

CW Zeng - International journal of molecular sciences, 2023 - mdpi.com
Spinal cord injuries (SCIs) can lead to significant neurological deficits and lifelong disability,
with far-reaching physical, psychological, and economic consequences for affected …