[HTML][HTML] Granzyme-producing CD4 T cells in cancer and autoimmune disease
CD4 T cells play important roles in promoting protective immunity and autoimmune disease.
A great deal of attention has been given to the differentiation and function of subsets of …
A great deal of attention has been given to the differentiation and function of subsets of …
Insights into the role of the JAK/STAT signaling pathway in graft-versus-host disease
Allogeneic hematopoietic transplantation (allo-HCT) is a curative therapy for a variety of
hematologic malignancies, primarily through immune-mediated clearance of malignant …
hematologic malignancies, primarily through immune-mediated clearance of malignant …
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Abstract Graft-vs.-host disease (GvHD) is a major complication of allogenic hematopoietic
stem-cell (HSC) transplantation. GvHD is associated with loss of endothelial …
stem-cell (HSC) transplantation. GvHD is associated with loss of endothelial …
[HTML][HTML] CD38brightCD8+ T cells associated with the development of acute GVHD are activated, proliferating, and cytotoxic trafficking cells
P Khandelwal, V Chaturvedi, E Owsley, A Lane… - Biology of Blood and …, 2020 - Elsevier
We have previously reported that a peripheral blood absolute CD38 bright CD8+ effector
memory T cell (TEM) population expansion of> 35 cells/µL predicts the development of …
memory T cell (TEM) population expansion of> 35 cells/µL predicts the development of …
Cytotoxic pathways in allogeneic hematopoietic cell transplantation
W Du, X Cao - Frontiers in immunology, 2018 - frontiersin.org
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment
for hematologic malignancies, and other hematologic and immunologic diseases. Donor …
for hematologic malignancies, and other hematologic and immunologic diseases. Donor …
Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials
R Thompson, X Cao - Frontiers in Immunology, 2024 - frontiersin.org
The pivotal role of Granzyme B (GzmB) in immune responses, initially tied to cytotoxic T
lymphocytes (CTLs) and natural killer (NK) cells, has extended across diverse cell types and …
lymphocytes (CTLs) and natural killer (NK) cells, has extended across diverse cell types and …
Murine regulatory T cells utilize granzyme B to promote tumor metastasis
Regulatory T cells (Tregs) possess a wide range of mechanisms for immune suppression.
Among them, Granzyme B (GzmB) and perforin expressed by Tregs were shown to inhibit …
Among them, Granzyme B (GzmB) and perforin expressed by Tregs were shown to inhibit …
Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII‐independent manner
B Stopnicki, M Blain, QL Cui, TE Kennedy, JP Antel… - Glia, 2019 - Wiley Online Library
During inflammatory processes of the central nervous system, helper T cells have the
capacity to cross the blood–brain barrier and injure or kill neural cells through cytotoxic …
capacity to cross the blood–brain barrier and injure or kill neural cells through cytotoxic …
Screening of four lysosome-related genes in sepsis based on RNA sequencing technology
G Chen, W Zhang, C Wang, M Chen, Y Hu, Z Wang - BMC immunology, 2023 - Springer
Purpose Screening of lysosome-related genes in sepsis patients to provide direction for
lysosome-targeted therapy. Methods Peripheral blood samples were obtained from 22 …
lysosome-targeted therapy. Methods Peripheral blood samples were obtained from 22 …
Serine protease inhibitor 6 protects alloreactive T cells from Granzyme B-mediated mitochondrial damage without affecting graft-versus-tumor effect
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for
hematologic malignancies. Donor T cells are able to eliminate residual tumor cells after allo …
hematologic malignancies. Donor T cells are able to eliminate residual tumor cells after allo …