Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in the developed
world. Accordingly, an urgent need exists for new, curative treatments as well as for …

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …

Fibroblasts from patients with Tangier disease carrying ATP-binding cassette A1 (ABCA1)
loss-of-function mutations are characterized by cardiolipin accumulation, a mitochondrial …

Background The glomerulus is a specialized capillary bed that is involved in urine
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic …

Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

The macro-and microvascular complications of type 1 and 2 diabetes lead to increased
disease severity and mortality. The receptor for advanced glycation end products (RAGE) …

Diabetic nephropathy is the leading cause of end-stage renal disease in humans in the
Western world. The recent development of Na+-glucose cotransporter 2 (SGLT2) inhibitors …

While there are many murine models of mesangial matrix expansion in the setting of
diabetes, few progress to develop advanced diabetic lesions. Mice with eNOS deficiency …

Excess levels of protein in urine (proteinuria) is a hallmark of kidney disease that typically
occurs in conjunction with diabetes, hypertension, gene mutations, toxins or infections but …

Diabetes is associated with activation of the polyol pathway, in which glucose is converted to
sorbitol by aldose reductase. Previous studies focused on the role of sorbitol in mediating …