Tumor immune evasion is a hallmark of Head and Neck Cancers. The advent of immune
checkpoint inhibitors (ICIs) in the first-line setting has transformed the management of these …

Although immune checkpoint-based cancer immunotherapy has shown significant efficacy
in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is …

Cells respond to DNA damage by activating a complex array of signaling networks, which
include the AMPK and mTOR pathways. After DNA double-strand breakage, ATM, a core …

Although cancer has long been considered a genetic disease, increasing evidence shows
that epigenetic aberrations play a crucial role in affecting tumor biology and therapeutic …

Epigenetic modifiers (miRNAs, histone methyltransferases (HMTs)/demethylases, and DNA
methyltransferases/demethylases) are associated with cancer proliferation, metastasis …

Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC)
is the sixth most common cancer type in the world and is associated with an overall poor …

The interplay between cancer and the immune system has captivated researchers for a long
time. Recent developments in cancer immunotherapy have substantiated this interest with a …

Head and neck squamous cell carcinoma (HNSCC) is a spectrum of heterogeneous
malignancies. A variety of genetic, environmental, and lifestyle factors contribute to the …

SET and MYND-domain containing protein 3 (SMYD3) mediates epigenetic repression of
type I IFN response genes in human papillomavirus (HPV)-negative HNSCC cells, and …

The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed
light on previously underappreciated biological mechanisms that promote diseases. With …