The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …
Discovery of shared genomic loci using the conditional false discovery rate approach
In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …
the statistical power has improved and thousands of trait-associated variants have been …
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable and a major determinant of human health and well-being.
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Accumulating evidence from genome wide association studies (GWAS) suggests an
abundance of shared genetic influences among complex human traits and disorders, such …
abundance of shared genetic influences among complex human traits and disorders, such …
The relationship between polygenic risk scores and cognition in schizophrenia
AL Richards, AF Pardiñas, A Frizzati… - Schizophrenia …, 2020 - academic.oup.com
Background Cognitive impairment is a clinically important feature of schizophrenia.
Polygenic risk score (PRS) methods have demonstrated genetic overlap between …
Polygenic risk score (PRS) methods have demonstrated genetic overlap between …
Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity
and overlapping symptoms. However, the causative mechanisms underlying this …
and overlapping symptoms. However, the causative mechanisms underlying this …
Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways
Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both
the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic …
the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic …
Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function
Importance Schizophrenia is associated with widespread cognitive impairments. Although
cognitive deficits are one of the factors most strongly associated with functional outcome in …
cognitive deficits are one of the factors most strongly associated with functional outcome in …
Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms
Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and
intracranial volume (ICV). However, little is known about the underlying etiology of these …
intracranial volume (ICV). However, little is known about the underlying etiology of these …