Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery

L Shi, J Zhang, M Zhao, S Tang, X Cheng, W Zhang… - Nanoscale, 2021 - pubs.rsc.org
The rapid development of drug nanocarriers has benefited from the surface hydrophilic
polymers of particles, which has improved the pharmacokinetics of the drugs. Polyethylene …

Polymeric micelles and cancer therapy: An ingenious multimodal tumor-targeted drug delivery system

SK Hari, A Gauba, N Shrivastava, RM Tripathi… - Drug Delivery and …, 2023 - Springer
Since the beginning of pharmaceutical research, drug delivery methods have been an
integral part of it. Polymeric micelles (PMs) have emerged as multifunctional nanoparticles in …

A review of research and application of polylactic acid composites

X Li, Y Lin, M Liu, L Meng, C Li - Journal of Applied Polymer …, 2023 - Wiley Online Library
Polylactic acid (PLA) is a thermoplastic polyester that has received widespread attention for
its environmentally friendly origin and excellent performance, and its potential to address the …

Cancer drug delivery in the nano era: An overview and perspectives

Z Li, S Tan, S Li, Q Shen, K Wang - Oncology reports, 2017 - spandidos-publications.com
Nanomaterials are increasingly used as drug carriers for cancer therapy. Nanomaterials
also appeal to researchers in the areas of cancer diagnosis and biomarker discovery …

Nanostructured carriers as innovative tools for cancer diagnosis and therapy

C Martinelli, C Pucci, G Ciofani - APL bioengineering, 2019 - pubs.aip.org
Cancer accounts for millions of deaths every year and, due to the increase and aging of the
world population, the number of new diagnosed cases is continuously rising. Although many …

Transport of PEGylated-PLA nanoparticles across a blood brain barrier model, entry into neuronal cells and in vivo brain bioavailability

JM Rabanel, PA Piec, S Landri, SA Patten… - Journal of Controlled …, 2020 - Elsevier
Treatments of neurodegenerative diseases (NDDs) are severely hampered by the presence
of the blood-brain barrier (BBB) precluding efficient brain drug delivery. The development of …

Curcumin and its nano-formulations: Defining triple-negative breast cancer targets through network pharmacology, molecular docking, and experimental verification

Z Deng, G Chen, Y Shi, Y Lin, J Ou, H Zhu… - Frontiers in …, 2022 - frontiersin.org
Background: Curcumin (CUR) displays the capability of suppressing the proliferation and
metastasis of various cancer cells. However, the effects and underline mechanisms of CUR …

A nanomedicine approach enables co-delivery of cyclosporin A and gefitinib to potentiate the therapeutic efficacy in drug-resistant lung cancer

W Han, L Shi, L Ren, L Zhou, T Li, Y Qiao… - Signal transduction and …, 2018 - nature.com
Drug resistance, accounting for therapeutic failure in the clinic, remains a major challenge to
effectively manage cancer. Cyclosporin A (CsA) can reverse multidrug resistance (MDR) …

Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion

JM Rabanel, M Mirbagheri, M Olszewski, G Xie… - ACS …, 2022 - ACS Publications
Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply
penetrating into dense tissues of the CNS could potentially transform the management of …

In situ characterization of the protein corona of nanoparticles in vitro and in vivo

PL Latreille, JM Rabanel, M Le Goas… - Advanced …, 2022 - Wiley Online Library
A new theoretical framework that enables the use of differential dynamic microscopy (DDM)
in fluorescence imaging mode to quantify in situ protein adsorption onto nanoparticles (NP) …