Forty years of research have established that the p53 tumor suppressor provides a major
barrier to neoplastic transformation and tumor progression by its unique ability to act as an …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …

In the past fifteen years, it has become apparent that tumour-associated p53 mutations can
provoke activities that are different to those resulting from simply loss of wild-type tumour …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

In cancer, the tumour suppressor gene TP53 undergoes frequent missense mutations that
endow mutant p53 proteins with oncogenic properties. Until now, a universal mutant p53 …

p53 is a master regulatory protein that participates in cellular processes such as apoptosis,
DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and …

The transcription factor p63 plays a pivotal role in keratinocyte proliferation and
differentiation in the epidermis. However, how p63 regulates epidermal genes during …

The tumor suppressor protein p53 loses its function in more than 50% of human malignant
tumors. Recent studies have suggested that mutant p53 can form aggregates that are …

The ubiquitin proteasome system (UPS) plays a role in the regulation of most cellular
pathways, and its deregulation has been implicated in a wide range of human pathologies …