Oxidative risk for atherothrombotic cardiovascular disease

JA Leopold, J Loscalzo - Free Radical Biology and Medicine, 2009 - Elsevier
In the vasculature, reactive oxidant species, including reactive oxygen, nitrogen, or
halogenating species, and thiyl, tyrosyl, or protein radicals may oxidatively modify lipids and …

Oxidative mechanisms and atherothrombotic cardiovascular disease

JA Leopold, J Loscalzo - Drug Discovery Today: Therapeutic Strategies, 2008 - Elsevier
Oxidant stress has been implicated in the etiology and pathogenesis of atherothrombotic
vascular disease. Elevated levels of reactive oxygen species, resulting from increased …

Aberrant gene expression of superoxide dismutases in Chlamydia trachomatis-infected recurrent spontaneous aborters

A Ray, T Bhati, D Pradhan, R Arora, S Parvez… - Scientific Reports, 2022 - nature.com
Study aimed to characterize the expression of antioxidant genes SOD1 and SOD2 in
Chlamydia trachomatis-induced recurrent spontaneous aborters and further determine their …

[HTML][HTML] Impact of azithromycin, doxycycline and redox-active small molecules on amoxicillin-induced Chlamydia pneumoniae persistence

E Taavitsainen-Wahlroos, I Reigada, I Sulmona… - Biomedicine & …, 2023 - Elsevier
Amoxicillin is recommended as primary treatment for community-acquired bacterial
pneumonia (CABP). 5–10% of CABP cases are caused by Chlamydia pneumoniae, an …

Chlamydia pneumoniae Infection in Atherosclerotic Lesion Development through Oxidative Stress: A Brief Overview

M Di Pietro, S Filardo, F De Santis, R Sessa - International Journal of …, 2013 - mdpi.com
Chlamydia pneumoniae, an obligate intracellular pathogen, is known as a leading cause of
respiratory tract infections and, in the last two decades, has been widely associated with …

Chlamydia pneumoniae and Oxidative Stress in Cardiovascular Disease: State of the Art and Prevention Strategies

M Di Pietro, S Filardo, F De Santis… - International journal of …, 2014 - mdpi.com
Chlamydia pneumoniae, a pathogenic bacteria responsible for respiratory tract infections, is
known as the most implicated infectious agent in atherosclerotic cardiovascular diseases …

Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study

A Marangoni, C Bergamini, R Fato, C Cavallini… - BMC research …, 2014 - Springer
Background An increasing number of studies suggest that chlamydiae can infect immune
cells. The altered immune cell function could contribute to the progression of several chronic …

Free intracellular Ca2+ regulates bacterial lipopolysaccharide induction of iNOS in human macrophages

AA Azenabor, P Kennedy, J York - Immunobiology, 2009 - Elsevier
Inducible nitric oxide synthase (iNOS) reaction is of enormous significance in innate immune
protective response of host to microbial challenges. We speculate that microbial challenges …

[HTML][HTML] Chlamydia trachomatis infection of human trophoblast alters estrogen and progesterone biosynthesis: an insight into role of infection in pregnancy sequelae

AA Azenabor, P Kennedy… - International journal of …, 2007 - ncbi.nlm.nih.gov
The trophoblast cells are in direct contact with endometrial tissues throughout gestation,
playing important early roles in implantation and placentation. The physiologic significance …

6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)-ethyl]-3H-quinazolin-4-one as an inhibitor of human phosphatidylinositol 3-kinase delta

EA Kesicki, KW Fowler, D Huang, HC Ooi… - US Patent …, 2014 - Google Patents
Compounds that inhibit PI3K6 activity, including compounds that selectively inhibit PI3K6
activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform …