Control of peptide conformation by the Thorpe‐Ingold effect (Cα‐tetrasubstitution)

C Toniolo, M Crisma, F Formaggio… - … : Original Research on …, 2001 - Wiley Online Library
The preferred conformations of peptides heavily based on the currently extensively exploited
achiral and chiral α‐amino acids with a quaternary α‐carbon atom, as determined by …

The spin label amino acid TOAC and its uses in studies of peptides: chemical, physicochemical, spectroscopic, and conformational aspects

S Schreier, JC Bozelli, N Marín, RFF Vieira… - Biophysical …, 2012 - Springer
We review work on the paramagnetic amino acid 2, 2, 6, 6-tetramethyl-N-oxyl-4-amino-4-
carboxylic acid, TOAC, and its applications in studies of peptides and peptide synthesis …

Internal dynamics of a supramolecular nanofibre

JH Ortony, CJ Newcomb, JB Matson, LC Palmer… - Nature materials, 2014 - nature.com
A large variety of functional self-assembled supramolecular nanostructures have been
reported over recent decades. The experimental approach to these systems initially focused …

Cell death versus cell survival instructed by supramolecular cohesion of nanostructures

CJ Newcomb, S Sur, JH Ortony, OS Lee… - Nature …, 2014 - nature.com
Many naturally occurring peptides containing cationic and hydrophobic domains have
evolved to interact with mammalian cell membranes and have been incorporated into …

A spirocyclohexyl nitroxide amino acid spin label for pulsed EPR spectroscopy distance measurements

A Rajca, V Kathirvelu, SK Roy, M Pink… - … A European Journal, 2010 - Wiley Online Library
Site‐directed spin labeling and EPR spectroscopy offer accurate, sensitive tools for the
characterization of structure and function of macromolecules and their assemblies. A new …

Orientation and immersion depth of a helical lipopeptaibol in membranes using TOAC as an ESR probe

V Monaco, F Formaggio, M Crisma… - Biopolymers …, 1999 - Wiley Online Library
Trichogin GA IV is a lipopeptaibol antibiotic characterized by the sequence nOct–Aib1–Gly–
Leu–Aib4–Gly–Gly–Leu–Aib8–Gly–Ile–Lol (nOct: n‐octanoyl; Aib: α‐aminoisobutyric acid; …

Trichogin: a paradigm for lipopeptaibols

C Peggion, F Formaggio, M Crisma… - Journal of Peptide …, 2003 - Wiley Online Library
Lipopeptaibols are members of a novel family of naturally occurring, short peptides with
antimicrobial activity, characterized by a lipophilic acyl chain at the N‐terminus, a high …

Tuning the properties of nitroxide spin labels for use in electron paramagnetic resonance spectroscopy through chemical modification of the nitroxide framework

MM Haugland, EA Anderson, JE Lovett - 2016 - books.rsc.org
Spin labels containing nitroxyl radicals possess many properties that render them useful for
electron paramagnetic resonance (EPR) spectroscopy. This review describes the …

Dynamics in supramolecular nanomaterials

Y Cho, T Christoff-Tempesta, SJ Kaser, JH Ortony - Soft Matter, 2021 - pubs.rsc.org
Self-assembly of amphiphilic small molecules in water leads to nanostructures with
customizable structure–property relationships arising from their tunable chemistries …

Generation of profluorescent isoindoline nitroxides using click chemistry

JC Morris, JC McMurtrie, SE Bottle… - The Journal of Organic …, 2011 - ACS Publications
Novel profluorescent nitroxides bearing a triazole linker between the coumarin fluorophore
and an isoindoline nitroxide were prepared in good yields using the copper-catalyzed azide …