Tissue development is orchestrated by the coordinated activities of both chemical and
physical regulators. While much attention has been given to the role that chemical regulators …

Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound
healing and normal organ homeostasis. Life-threatening pathological conditions arise when …

Human tissues must be elastic, much like other materials that work under continuous loads
without losing functionality. The elasticity of tissues is provided by elastin, a unique protein of …

The extracellular matrix is an integral and dynamic component of all tissues.
Macromolecular compositions and structural architectures of the matrix are tissue-specific …

The quality of life of ageing populations is increasingly determined by age-related changes
to the mechanical properties of numerous biological tissues. Degradation and mechanical …

The ability of elastic tissues to deform under physiological forces and to subsequently
release stored energy to drive passive recoil is vital to the function of many dynamic tissues …

Thoracic aortic aneurysms (TAA) increase the risk of aortic dissection or rupture and
represent an important source of morbidity and mortality. Inherited forms of the disease …

Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of
connective tissue with prominent manifestations in the skeletal, ocular, and cardiovascular …

The biomechanical properties of connective tissues play fundamental roles in how
mechanical interactions of the body with its environment produce physical forces at the …

The lung parenchyma comprises a large number of thin-walled alveoli, forming an
enormous surface area, which serves to maintain proper gas exchange. The alveoli are held …