Osteopontin (OPN) is a multifunctional cytokine that impacts cell proliferation, survival, drug
resistance, invasion, and stem like behavior. Due to its critical involvement in regulating …

NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

Distance distribution information obtained by pulsed dipolar EPR spectroscopy provides an
important contribution to many studies in structural biology. Increasingly, such information is …

Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …

Intrinsically disordered proteins (IDPs) are characterized by substantial conformational
plasticity. Given their inherent structural flexibility X-ray crystallography is not applicable to …

Since its initial identification as one of the genes most highly upregulated upon T-cell
activation, osteopontin (or Eta-1, as it was designated then) has been demonstrated to have …

Intrinsically disordered proteins (IDPs) carry out many biological functions. They lack a
stable three-dimensional structure, but rather adopt many different conformations in dynamic …

Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer's disease
with Tau oligomers suspected as the most toxic agent. Tau is a client of the molecular …

Despite significant advances in the understanding of cancer biology, cancer is still a leading
cause of death worldwide. Expression of the tumor microenvironment component …

The characterization of structure and dynamics of macromolecular and supramolecular
systems represents an ongoing challenge. This is due to the fact that soft matter systems …