The interaction of cells within their microenvironmental niche is fundamental to cell
migration, positioning, growth and differentiation in order to form and maintain complex …

Second harmonic generation (SHG) and third harmonic generation (THG) microscopies
have emerged as powerful imaging modalities to examine structural properties of a wide …

Second-harmonic generation (SHG) microscopy has emerged as a powerful modality for
imaging fibrillar collagen in a diverse range of tissues. Because of its underlying physical …

Rete ridges (RRs) are distinct undulating microstructures at the junction of the dermis and
epidermis in the skin of humans and certain animals. This structure is essential for …

Second-harmonic generation (SHG) microscopy began to emerge as a high-resolution
optical imaging modality in the late 1990s, about 10 years after two-photon excited …

Histological visualizations are critical to clinical disease management and are fundamental
to biological understanding. However, current approaches that rely on bright-field …

Light-based diagnostics and therapy have become indispensable tools in the field of cancer
nanomedicine. Various optical imaging modalities with tomographic capability have been …

Surgical oncologists depend heavily on visual field acuity during cancer resection surgeries
for in-situ margin assessment. Clinicians must wait up to two weeks for results from a …

The last 30 years has seen great advances in optical microscopy with the introduction of
sophisticated fluorescence-based imaging methods such as confocal and multiphoton laser …

Raman sensing and microscopy are among the most specific optical technologies to identify
the chemical compounds of unknown samples, and to enable label-free biomedical imaging …