From a molecular perspective, enactors of function in biology are intact proteins that can be
variably modified at the genetic, transcriptional, or post-translational level. Over the past 30 …

Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …

MALDI imaging mass spectrometry is a powerful analytical tool enabling the visualization of
biomolecules in tissue. However, there are unique challenges associated with protein …

Mass spectrometry imaging (MSI) has become a widespread analytical technique to perform
nonlabeled spatial molecular identification. The Achilles' heel of MSI is the annotation and …

Unraveling the complexity of biological systems relies on the development of new
approaches for spatially resolved proteoform‐specific analysis of the proteome. Herein, we …

Top‐down proteomics is emerging as a preferred approach to investigate biological
systems, with objectives ranging from the detailed assessment of a single protein …

Over the last decade mass spectrometry imaging (MSI) has been integrated in to many
areas of drug discovery and development. It can have significant impact in oncology drug …

Despite intense scientific efforts, the neuropathology and pathophysiology of schizophrenia
are poorly understood. Proteomic studies, by testing large numbers of proteins for …

Background Recently, it was demonstrated that proteins can be translated from alternative
open reading frames (altORFs), increasing the size of the actual proteome. Top-down mass …

Tissue spatially-resolved proteomics was performed on 3 brain regions, leading to the
characterization of 123 reference proteins. Moreover, 8 alternative proteins from alternative …