TGF-β signaling controls a plethora of cellular responses and figures prominently in animal
development. Recent cellular, biochemical, and structural studies have revealed significant …

Since their original discovery as regulators of follicle-stimulating hormone (FSH) secretion
and erythropoiesis, the TGF-β family members activin and inhibin have been shown to …

Activins and inhibins, structurally related members of the TGF-β superfamily of growth and
differentiation factors, are mutually antagonistic regulators of reproductive and other …

Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors
(GDFs) form the largest subgroup of the Transforming Growth Factor (TGF) β family and …

When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic
hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years …

Expression microarrays are widely used for investigating the candidate molecular targets in
human cancer. While genome-wide expression signatures screened by gene set enrichment …

The crystal structure of the complete signaling complex formed between bone
morphogenetic protein 2 (BMP-2) and the extracellular domains (ECDs) of its type I receptor …

It has been 70 years since the name inhibin was used to describe a gonadal factor that
negatively regulated pituitary hormone secretion. The majority of this period was required to …

Members of the transforming growth factor β (TGF-β) superfamily of cell signalling
polypeptides have attracted much attention because of their ability, from nematodes to …

Bone morphogenetic proteins (BMPs) belong to the large transforming growth factor-β (TGF-
β) superfamily of multifunctional cytokines. BMP-2 can induce ectopic bone and cartilage …