The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of
heme degradation. Induction of HO-1 protects against the cytotoxicity of oxidative stress and …

Hydrogen sulfide (H2S), a regulatory gaseous molecule that is endogenously synthesized
by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS) from L-cysteine (L …

The ability to communicate with the environment and respond to changes—particularly
those of an adverse nature—within that environment is critical for cell function and survival …

Nitroalkene derivatives of linoleic acid (LNO 2) and oleic acid (OA-NO 2) are present;
however, their biological functions remain to be fully defined. Herein, we report that LNO 2 …

Citation Soleymaninejadian E, Pramanik K, Samadian E. Immunomodulatory properties of
mesenchymal stem cells: cytokines and factors. Am J Reprod Immunol 2012; 67: 1–8 …

Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin,
has been recognized as playing a crucial role in cellular defense against stressful …

Abstract The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9 (11)-dien-28-oic acid
(CDDO) and its derivative 1-[2-cyano-3-, 12-dioxooleana-1, 9 (11)-dien-28-oyl] imidazole …

Nuclear factor erythroid 2-related factor 2 (Nrf2) mediates the transcriptional response of
cells to oxidative stress and is translocated into the nucleus following, or concomitant with …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. Many biological …