The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Motor proteins are key players in exerting spatiotemporal control over the intracellular
location of membrane-bound compartments, including endosomes containing cargo. In this …

Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse
cellular functions including cell survival, metabolism, and transcription. As a result …

Microtubules are highly polar structures and are characterized by high anisotropy and
stiffness. In neurons, they play a key role in the directional transport of vesicles and …

Cytoplasmic dynein-driven movement of chromosomes during prophase I of mammalian
meiosis is essential for synapsis and genetic exchange. Dynein connects to chromosome …

Precise spatiotemporal control of microtubule nucleation and organization is critical for
faithful segregation of cytoplasmic and genetic material during cell division and signaling via …

The connexin gene family is the most prevalent gene that contributes to hearing loss.
Connexins 26 and 30, encoded by GJB2 and GJB6, respectively, are the most abundantly …

Cancer is one of the leading causes of death worldwide. There are only limited treatment
strategies that can be applied to treat cancer, including surgical resection, chemotherapy …

Accompanying the precipitous age-related decline in human female fertility is an increase in
the proportion of poor-quality oocytes within the ovary. The macroautophagy pathway, an …