Functional data analysis (FDA) involves the analysis of data whose ideal units of
observation are functions defined on some continuous domain, and the observed data …

The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …

Pancreatic cancer continues to pose an enormous challenge to clinicians and cancer
scientists. With a more affluent world the global incidence of pancreatic cancer is rising. For …

Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance
of multiple cancers. Yet functional interactions between specific signaling pathways in solid …

Background: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
(MALDI-TOF MS) and the related technique, surface-enhanced laser desorption/ionization …

The synthesis of acute-phase protein serum amyloid A (SAA) is largely regulated by
inflammation-associated cytokines and a high concentration of circulating SAA may …

Pancreatic cancer is a deadly disease and the fourth most common cause of cancer death in
the United States. Since chemotherapy and radiotherapy have thus far largely failed to …

Background: Periodontal pathogens have been linked to oral and gastrointestinal
(orodigestive) carcinogenesis. However, the exact mechanisms remain unknown …

Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis.
Early detection greatly improves prognosis; however, the invasive, unpleasant and …

In this article, we present an overview of the different strategies for sample preparation for
identification by mass spectrometry (MS) of biomarkers from serum and/or plasma. We …