[HTML][HTML] Neurotoxicity from long-term exposure to 6-PPDQ: Recent advances

CS Ma, DL Li, F Wang, JP Wang, MT He - … and Environmental Safety, 2024 - Elsevier
The recent acceleration of industrialization and urbanization has brought significant
attention to N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ), an …

6-PPD quinone at environmentally relevant concentrations induced damage on longevity in C. elegans: Mechanistic insight from inhibition in mitochondrial UPR …

X Hua, D Wang - Science of The Total Environment, 2024 - Elsevier
PPD quinone (6-PPDQ) exists widely in water environment media, causing acute lethality to
some aquatic species. Long-term exposure to 6-PPDQ reduced the lifespan of …

Environmentally Relevant Concentrations of S-6PPD-Quinone Caused More Serious Hepatotoxicity Than R-Enantiomer and Racemate in Oncorhynchus mykiss

S Di, H Xu, Y Yu, P Qi, Z Wang, Z Liu… - Environmental …, 2024 - ACS Publications
6PPD-quinone (6PPD-Q) is frequently detected in various environmental media, and the
environmentally relevant concentrations can be fatal to Oncorhynchus mykiss. Notably …

Environmental occurrence, fate, human exposure, and human health risks of p-phenylenediamines and their quinones

R Shi, Z Zhang, A Zeb, X Fu, X Shi, J Liu, J Wang… - Science of The Total …, 2024 - Elsevier
P-phenylenediamine antioxidants (PPDs) are widely used in the rubber industry and their
release and transformation in the environment has become one of the current environmental …

Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Z Liu, Q Bian, D Wang - Journal of Hazardous Materials, 2024 - Elsevier
Abstract Exposure to N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-
PPDQ) caused toxicity on Caenorhabditis elegans, including reproductive toxicity. However …

Occurrence of Multiple Classes of Emerging Synthetic Antioxidants, Including p-Phenylenediamines, Diphenylamines, Naphthylamines, Macromolecular Hindered …

B Liang, J Ge, Q Deng, Y Li, B Du, Y Guo… - … Science & Technology …, 2024 - ACS Publications
Synthetic antioxidants (AOs) have received increasing attention in recent years due to their
environmental ubiquity. However, lactational exposure to these emerging contaminants of …

Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

X Hua, G Liang, J Chao, D Wang - Journal of Hazardous Materials, 2024 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) is an
emerging pollutant transformed from 6-PPD. However, the effect of 6-PPDQ exposure on …

Toxicity of substituted p-phenylenediamine antioxidants and their derived novel quinones on aquatic bacterium: Acute effects and mechanistic insights

W Wang, Y Chen, J Fang, F Zhang, G Qu… - Journal of Hazardous …, 2024 - Elsevier
Substituted para-phenylenediamines (PPDs) are synthetic chemicals used globally for
rubber antioxidation, with their quinone derivatives (PPD-Qs) raising particular …

6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage

B Fu, T Chen, B Jiang, H Feng, Z Zhu, M Li… - Environmental …, 2024 - Elsevier
Recently, attention has been drawn to the adverse outcomes of N-(1, 3-Dimethylbutyl)-N′-
phenyl-p-phenylenediamine quinone (6PPDQ) on human health, but its cardiac toxicity has …

A nation-wide study for the occurrence of PPD antioxidants and 6PPD-quinone in road dusts of China

Y Zhang, L Yan, L Wang, H Zhang, J Chen… - Science of The Total …, 2024 - Elsevier
Abstract N, N′-substituted p-phenylenediamines (PPDs) are widely used antioxidants in
rubber tires, which could be released and accumulated in road dusts with rubber tires wear …