The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function
is undeniable. Evidence indicates that this transcription factor exerts massive regulatory …

Nrf2 [nuclear factor erythroid 2-related factor 2 (Nrf2)] regulates the expression of a plethora
of genes involved in the response to oxidative stress due to inflammation, aging, and tissue …

The oxidative burst generated by the host immune system can restrict intracellular parasite
entry and growth. While this burst leads to the induction of antioxidative enzymes, the …

Among the gastrointestinal nematodes affecting sheep, Haemonchus contortus is the most
prevalent and virulent, resulting in health problems and production losses. Therefore …

Treatment of leishmaniasis is a challenging subject. Although available, chemotherapy is
limited, presenting toxicity and adverse effects. New drugs with antileishmanial activity are …

Macrophage–Leishmania interactions are central to parasite growth and disease outcome.
Macrophages have developed various strategies to fight invaders, including oxidative burst …

Leishmaniasis is a widespread group of neglected vector-borne tropical diseases that
possess serious therapeutic limitations. Propolis has been extensively used in traditional …

We showed previously that antioxidant enzyme heme oxygenase 1 (HO-1) is critical for
Leishmania survival in visceral leishmaniasis. HO-1 inhibits host oxidative burst and …

One of the main components of innate defense against invasive parasites is oxidative stress,
which is brought on by reactive oxygen species (ROS). On the other hand, oxidative …

Background In the Mediterranean basin, three Leishmania species have been identified: L.
infantum, L. major and L. tropica, causing zoonotic visceral leishmaniasis (VL), zoonotic …