Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

The microtubule-binding interface of the kinetochore is of central importance in chromosome
segregation. Although kinetochore components that stabilize, translocate on, and affect the …

Kinetochores are macromolecular machines that couple chromosomes to dynamic
microtubule tips during cell division, thereby generating force to segregate the …

Kinetochores are the macromolecular complexes that interact with microtubules to mediate
chromosome segregation [1]. Accurate segregation requires that kinetochores make …

Developmental stages in multicellular organisms proceed according to a temporally and
spatially precise pattern of gene expression. It has become evident that changes within the …

Kinetochores are large protein assemblies built on chromosomal loci named centromeres.
The main functions of kinetochores can be grouped under four modules. The first module, in …

Regulated interactions between kinetochores and spindle microtubules are essential to
maintain genomic stability during chromosome segregation. The Aurora B kinase …

Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle
microtubules to promote chromosome segregation. The 10-subunit KMN assembly …

Centromeres contain specialized chromatin that includes the centromere-specific histone H3
variant, spCENP-A/Cnp1. Here we report identification of five fission yeast centromere …