The recent cloning and sequencing of several insect vitellogenins (Vg), the major yolk
protein precursor of most oviparous animals, and the mosquito Vg receptor (VgR) has …

The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …

Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults,
and one-third of patients develop end-stage renal disease (ESRD). Circulating …

Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the
body weight by balancing food intake and energy expenditure. However, this adipocyte …

Megalin is an endocytic receptor expressed on the luminal surface of the renal proximal
tubules. The receptor is believed to play an important role in the tubular uptake of …

Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease
characterized by destabilization of podocyte foot processes. We report that transgenic …

Vacuolar H+-ATPases are ubiquitous multisubunit complexes mediating the ATP-dependent
transport of protons. In addition to their role in acidifying the lumen of various intracellular …

The multiligand, endocytic receptors megalin and cubilin are colocalized in the renal
proximal tubule. They are heavily expressed in the apical endocytic apparatus. Megalin is a …

A soluble form of Alzheimer disease amyloid beta-protein (sA beta) is transported in the
blood and cerebrospinal fluid mainly complexed with apolipoprotein J (apoJ). Using a well …

While a variety of factors act to trigger or initiate autoimmune diseases, the process of
epitope spreading is an important contributor in their development. Epitope spreading is a …