Ferulic acid, a kind of phenolic substance widely existing in plants, is an important active
component of many traditional Chinese medicines. So far, it has been proved that ferulic …

The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …

Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …

Acute kidney injury (AKI) is a common clinical problem, characterized by a sudden loss of
renal function, a high risk of death, and the eventual development of renal fibrosis and renal …

Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical
application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive …

Highlights•Naringin induced a marked decrease of renal injury markers in MTX-treated
rats.•Naringin protected against redox imbalance of renal tissue in MTX-treated …

Pyroptosis mediated by nucleotide-binding oligomerization domain (NOD)-like receptor 3
(NLRP3) inflammasome is implicated in cerebral ischemia/reperfusion (I/R) injury …

Nephrotoxicity is a major complication that limits the therapeutic application of cisplatin
(CIS). Oxidative stress and inflammation are implicated in CIS-induced acute kidney injury …

Polyphenol compounds are natural antioxidants, which are rich in anti-inflammatory and
antioxidant components. They have a wide range of medicinal benefits that are believed to …

The Equisetum genus, Equisetaceae family, is widely distributed worldwide and may be the
oldest nonextinct genus on Earth. There are about 30 known species, which are very often …