The 5-HT3 receptor is a member of the Cys-loop family of ligand-gated ion channels. These
receptors are located in both the peripheral and central nervous systems, where functional …

HT 3 receptor antagonists, first introduced to the market in the mid-1980s, are proven
efficient agents to counteract chemotherapy-induced emesis. Nonetheless, recent …

Abstract Serotonin (5‐hydroxytryptophan [5‐HT]) is a biologically active amine expressed in
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …

Alcohol and drug abuse continue to be a major public health problem in the United States
and other industrialized nations. Extensive preclinical research indicates the mesolimbic …

A new chitosan derivative, N-guanidinium chitosan acetate, has been synthesized by direct
guanylation of chitosan by cyanamide in presence of scandium (III) triflate under mild acidic …

Synthesis and pharmacological evaluation of a series of condensed quinoline and pyridine
derivatives bearing a N-methylpiperazine moiety attached to the 2-position of the quinoline …

Amino-6-chloro-3, 4-dihydroquinazoline HCl (A6CDQ, 4) binds at 5-HT 3 serotonin
receptors and displays antidepressant-like action in the mouse tail suspension test (TST) …

Guanylation proceeded efficiently upon treatment of the various amines with cyanamide in
the presence of catalytic amounts of scandium (III) triflate under mild conditions. The method …

Objectives. To determine the effects of neurotrophin-secreting transplants combined with
exercise and serotonergic drug challenges on recovery of hindlimb function in rats with …

The direct serotonergic agonist, m-chlorophenylpiperazine (m-CPP), displays high efficacy
at 5-HT2C receptors. Systemic administration of m-CPP increased dramatically the …