Carbohydrates are attached and removed in living systems through the action of
carbohydrate‐active enzymes such as glycosyl transferases and glycoside hydrolases. The …

A new series of 7-substituted coumarin scaffolds containing a methyl ester moiety at the C4-
position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 …

The retaining endo-β-D-glucuronidase Heparanase (HPSE) is the primary mammalian
enzyme responsible for breakdown of the glycosaminoglycan heparan sulfate (HS). HPSE …

Abstract The North American beaver (Castor canadensis) has long been considered an
engineering marvel, transforming landscapes and shaping biological diversity through its …

Plant cell walls are composed of cellulose, hemicellulose, and lignin, collectively known as
lignocellulose. Microorganisms degrade lignocellulose to liberate sugars to meet metabolic …

Functional metagenomics has opened new opportunities for enzyme discovery. To exploit
the full potential of this new tool, the design of selective screens is essential, especially …

As part of a search for a substrate for droplet-based microfluidic screening assay of α-N-
acetylgalactosaminidases, spectral and physical characteristics of a series of coumarin …

Microbial polysaccharides composed of N-acetylglucosamine (GlcNAc), such as chitin,
peptidoglycan and poly-β-(1→ 6)-GlcNAc (dPNAG), play a critical role in maintaining cell …

In the current study, unique series of coumarin sulfonate and sulfamate derivatives were
synthesized. Their selectivity and inhibitory activity against glaucoma and cancer-associated …

Microorganisms routinely perform complex enzymatic transformations of natural material;
thus, their enzymes have the potential to tackle medical and industrial challenges. However …